Mouse Protein Z-Dependent Protease Inhibitor, native recombinant

Mouse Protein Z-Dependent Protease Inhibitor ZPI, recombinantly produced in insect cells. Active and complexable with Factor XIa. This Serine Protease Inhibitor SERPIN requires the cofactors Protein Z, phospholipids and calcium to inhibit endogenous Factor Xa. ZPI contains a tyrosine residue at the P1 position of the reactive center loop, rather than arginine which is present in most SERPINs.
References
1. Han, X. et al. 1998 PNAS 95:92509255.
2. Huang, X. et al. 2008 J. Biol. Chem. 283:2977029783.

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Supplier: Molecular Innovations