Peak 2 Purified Fibrinogen

It has been known for many years Mosseson MW & FinlaysonS. Lab Clin Med 62:663, 1963 that human fibrinogen can be sufractionated chromatographically into two peaks called Peak 1 and Peak 2 Fibrinogen respectively. These fibrinogens differ from one another with respect to their gamma chain composition. Peak 1 fibrinogen accounts for 85% of the total plasma fibrinogen and has two gamma-A chains, whereas Peak 2 fibrinogen accounts for the remaining 15% and contains one gamma-A chain and one gamma chain per molecule. Peak 1 fibrinogen contains mostly intact A-alpha subunit chains, is free of plasminogen, factor XIII, fibronectin, and other non-fibrinogen protein contaminants. Peak 1 fibrinogen molecules each contain two copies of the platelet-binding gamma-A chain C-terminal sequence and are ideal substrates for factor XIII assay. Peak 2 fibrinogen contains measurable amounts of factor XIII activity because the factor XIII B subunits bind to gamma chains and bring catalytic A subunits along with them. Thus Peak 2 fibrinogen serves as a carrier for factor XIII in blood. The gamma chain lacks the platelet recognition sequence but, like all gamma chains, become crosslinked to dimers by factor XIIIa.Molecular Weights:Peak 1 = 340,000 daltonsPeak 2 = 342,000 daltonsExtinction Coefficients:Peak 1 = 15.1Peak 2 = 15.1Clottability = > 95%

Size: 10 mg
Source: Human
Storage temperature: +2-8c
Transport temperature: Room Temperature

Delivery time: 2-14days

Supplier: Enzyme Research