Anti-FANCD2 Antibody

Polyclonal antibody for FANCD2 detection. Host: Rabbit.Size: 100&mul. Tested applications: WB. Reactive species: Human. FANCD2 information: Molecular Weight: 164128 MW Subcellular Localization: Nucleus . Concentrates in nuclear foci during S phase and upon genotoxic stress. At the onset of mitosis, excluded from chromosomes and diffuses into the cytoplasm, returning to the nucleus at the end of cell division. Observed in a few spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites and could be sites of replication fork stalling. The foci are frequently interlinked through BLM-associated ultra-fine DNA bridges. Following aphidicolin treatment, targets chromatid gaps and breaks Tissue Specificity: Highly expressed in germinal center cells of the spleen, tonsil, and reactive lymph nodes, and in the proliferating basal layer of squamous epithelium of tonsil, esophagus, oropharynx, larynx and cervix. Expressed in cytotrophoblastic cells of the placenta and exocrine cells of the pancreas (at protein level). Highly expressed in testis, where expression is restricted to maturing spermatocytes.

Size: 100ul
Source: Rabbit
Reactivity: Human, Mouse, Rat
Purity: Immunogen affinity purified
Application: WB
Immunogen: Synthesized peptide derived from human FANCD2 around the non-phosphorylation site of S222.
Storage temperature: Store at -20°C for one year, at 4°C for one month. We suggest the antibody be aliquotted into small vials and stored frozen at -20°C upon receiving. Avoid repeated freezing and thawing.
Transport temperature: Shipped with wet ice

Supplier: Bosterbio