Recombinant Human sIL-2R Alpha Protein

The IL-2 receptor system consists of three non-covalently linked subunits termed IL-2R&alpha, IL-2R&beta, and IL-2R&gamma. The IL-2R&alpha is a type I transmembrane protein consisting of a 219 amino acid extracellular domain, a 19 amino acid transmembrane domain and a 13 amino acid intracellular domain, which is not involved in the transduction of IL-2 signals. Proteolytic processing of IL-2R&alpha releases the entire extracellular domain of IL-2R&alpha thereby generating a 219 amino acid soluble protein called soluble IL-2R&alpha (sIL-2R&alpha). The homodimeric form binds IL-2 (KD=10nM) and facilitates IL-2 signaling. The secreted sIL-2R&alpha is expressed on leukemia cells, lymphoma cells, newly activated T and B cells, as well as on approximately 10% of NK cells. Recombinant human sIL-2R&alpha is a 24.8 kDa protein containing 219 amino acid residues consisting of only the extracellular domain of IL-2R&alpha. Due to glycosylation, IL-2R&alpha has an approximate molecular weight of 31 kDa based on SDS-PAGE gel and Mass Spectrometry.* Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

Size: 25µg
Source: (BTI-Tn-5B1-4) Hi-5 Insect cells*
Application: Cell Culture
Storage temperature: Store in -20°C for long term storage. After reconstitution, store in 4°C for short term usage within a few days. Avoid freeze-thaw cycles.
Transport temperature: Shipped with wet ice

Supplier: Bosterbio