Anti-SMC1 Antibody

Polyclonal antibody for SMC1/SMC1A detection. Host: Rabbit.Size: 100&mul. Tested applications: WB. Reactive species: Human. SMC1/SMC1A information: Molecular Weight: 143233 MW Subcellular Localization: Nucleus . Chromosome . Chromosome, centromere, kinetochore . Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere- kinetochore complex at the kinetochore region during mitosis.

Size: 100ul
Source: Rabbit
Reactivity: Human, Mouse
Purity: Immunogen affinity purified
Application: WB
Immunogen: Synthesized peptide derived from human SMC1 around the non-phosphorylation site of S957.
Storage temperature: Store at -20°C for one year, at 4°C for one month. We suggest the antibody be aliquotted into small vials and stored frozen at -20°C upon receiving. Avoid repeated freezing and thawing.
Transport temperature: Shipped with wet ice

Supplier: Bosterbio